• br Discussion Our results confirm that germline

  2019-05-20

  

  Discussion Our results confirm that germline variations in the TPMT gene are associated with treatment outcome in children with ALL [5]. The ability of TPMT to catalyze S-methylation and inactivate 6-mercaptopurine makes it a major determinant of 6-mercaptopurine toxicity. Furthermore, reduced TP

• br Water the main component of Earth s ecosystems

  2019-05-20

  

  Water—the main component of Earth\'s ecosystems—concentrates some of the most worrying global concerns that have emerged during the Anthropocene. When it comes to health considered at a planetary level, the challenges related to water can be sorted into five main categories: pollution, access to w

• In this study the distribution

  2019-05-20

  

  In this study, the distribution of LPs was also analyzed. Similar to previously published data, there was a tendency that vLPs were more frequently observed in patients with ICM than in patients with NICM. However, the total number of those abnormal ventricular electrograms was less documented than

• br Catheter ablation A reentry circuit is supported by compl

  2019-05-20

  

  Catheter ablation A reentry circuit is supported by complex anatomy and a thick and/or damaged myocardium; thus, high-energy RF application is usually required to create the conduction block line through the critical isthmus of the reentry circuit in patients after ToF repair. A large-tip (8mm) a

• br Future potential cardiac examinations for

  2019-05-20

  

  Future potential cardiac examinations for long-duration spaceflights Currently available treatments for emergency cases in spaceflight Astronaut Crew Medical Officers (CMO) aboard the ISS receive 40–70h of medical training, including CPR training, within 18 months preceding their mission (Fig.

• En este proceso de integraci n y

  2019-05-20

  

  En este proceso de integración y unidad latinoamericana y caribeña, la imagen política y diplomática de Estados Unidos se vio seriamente mermada por su terrible campaña contra el terrorismo. Su economía se mantiene sumergida en una aguda crisis financiera desde 2008, la más profunda desde 1929. A pe

• Esta postura foi decisiva para as alian

  2019-05-20

  

  Esta postura foi decisiva para as alianças confeccionadas pelas lideranças políticas e/ou religiosas (neo) pentecostais nas eleições seguintes. O apoio a Collor em 1989 e a Fernando Henrique Cardoso em 1994 teve como objetivo a oposição ao candidato Lula, do Partido dos Trabalhadores (pt), à Presidê

• O quilombo caracterizado como uma associa o guerreira aberta

  2019-05-20

  

  O quilombo é caracterizado como uma associação guerreira aberta, sem distinção de linhagens e transcultural. A transculturalidade vem das contribuições de povos distintos, com destaque para os imbangala. No ritual de iniciação dos imbangala, aldehyde dehydrogenase inhibitor circuncisão representava

• Similar to HF myocardial infarction MI

  2019-05-18

  

  Similar to HF, myocardial infarction (MI) is followed by significant down-regulation of multiple K currents in the peri-infarct zone. These changes may contribute to after-depolarization and ventricular arrhythmia in MI ventricles. However, none of the previous studies reported MI in an increased IK

• br Future perspectives Identification of LOX

  2019-05-18

  

  Future perspectives Identification of LOX as a modulator of the ECM to form pre-metastatic niches and subsequently bone metastasis arose as we were investigating the hypoxia tumour secretome using existing patient cohort data and cutting edge proteomics. Although condoned by some researchers as “

• br Case report At that time

  2019-05-17

  

  Case report At that time, her laboratory examinations showed hemoglobin (Hb) of 10.4 g/dl (normal: 11.3–15.3), and platelets of 36,000/mm3 (normal: 150,000–400,000), and WBC count of 3800/mm3 (normal: 4000–11,000). The liver function showed serum albumin was 3.2 g/dl, total bilirubin was 1.7 mg/d

• Where does this leave the other potential vaccines

  2019-05-17

  

  Where does this leave the other potential vaccines, and what additional information is required to inform their use? Many of these vaccines are based on a non-replicating adenoviral vector modified to express the Ebola glycoprotein (eg, adenovirus 5 (Ad5-ZEBOV), chimpanzee adenovirus 3 (Chad3), or a

• Several true lumen re entry devices have been introduced

  2019-05-17

  

  Several true lumen re-entry devices have been introduced into the market, including the Outback catheter, allowing fluoroscopically controlled true arterial lumen re-entry after subintimal guidewire passage. A recent retrospective review reported a successful re-entry rate of 91% in 11 patients with

• MADIT trial enrolled adult patients

  2019-05-17

  

  MADIT trial enrolled 196 adult patients with prior myocardial infarction more than 3 weeks (Q wave or elevated cardiac enzyme), with non-sustained ventricular tachycardia (a run of 3–30 of ventricular ectopic beats with a rate more than 120 beats per minute), with left ventricular ejection fraction

• The ability of tumors to

  2019-05-17

  

  The ability of tumors to progress to more malignant phenotypes depends on tumor microenvironment. Blood capillaries, made up of endothelial cells, are usually static under physiological conditions but are induced to proliferate by direct exposure to angiogenic factors, for instance, vascular endothe

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