• XMD8-92 Roux en Y gastric bypass surgery

  2019-05-07

  

  Roux-en-Y gastric bypass surgery is a common cause of malabsorption associated with hyperoxaluria in obese patients and those with malignancies. Postoperatively, patients may have steatorrhea, weight loss, and diarrhea, resulting in malabsorption syndrome, which would increase excessive intraluminal

• HCV does not kill the cells it infects

  2019-05-06

  

  HCV does not kill the more helpful hints it infects, but triggers an immune-mediated inflammatory response (hepatitis) that either rapidly clears the infection or slowly destroys the liver, causing the development of HCC and cirrhosis. The outcome is largely determined by the efficiency of the antiv

• mtor pathway Performing an ajmaline test in children is prob

  2019-05-06

  

  Performing an ajmaline test in children is problematic for 2 reasons. First, the test is apparently less sensitive in children than in adults. In fact, in 1 study, a repeat ajmaline challenge performed after puberty unmasked BrS in 23% of relatives with a previously negative drug test performed duri

• Contributors Conflicts of interest br Acknowledgments This r

  2019-05-06

  

  Contributors Conflicts of interest Acknowledgments This research was funded by the Bill & Melinda Gates Foundation. The views expressed herein are those GSK2126458 of the authors and do not necessarily represent the official policy or position of the Bill & Melinda Gates Foundation, Imperial Co

• Interim measures however are not nearly enough A massive

  2019-05-06

  

  Interim measures, however, are not nearly enough. A massive expansion of the blood donor pool is needed, but scaling up blood donation in the low-resource world is no easy task. WHO has long advocated a set of interventions to fortify a nation\'s blood supply, but countries will have difficulty solv

• br Genetic basis Similar to other

  2019-05-06

  

  Genetic basis Similar to other arrhythmia syndromes, Brugada and early repolarization syndromes are inherited diseases that are usually transmitted in an autosomal-dominant manner [26]. To date, 13 genes have been associated with Brugada syndrome. Loss-of-function mutations in SCN5A, encoding the

• br Conflict of interest br Introduction A large

  2019-05-06

  

  Conflict of interest Introduction A large number of recent reports suggest that early repolarization (ER) and J waves are associated with the occurrence of ventricular fibrillation (VF) [1–4]. In particular, the presence of J waves in global leads, including the inferolateral leads, is thought

• br Discussion Clinically HES may

  2019-05-06

  

  Discussion Clinically, HES may be separated into two subgroups: HES with, and HES without gene abnormality such as PDGFRA, PDGFRB, or FGFR1. The standard therapy of HES without gene abnormality is steroid; by contrast, the first-line therapy of HES with gene abnormality is imatinib. Although in-

• Surgery especially modified radical mastectomy is the gold

  2019-05-06

  

  Surgery, especially modified radical mastectomy, is the “gold standard” for the treatment of male breast cancer. Postoperative adjuvant radiotherapy is recommended for male patients with large breast cancer and axillary lymph node and chest muscle involvement; it can reduce the risk of local cancer

• According to the labeling of dabigatran in Japan patients to

  2019-05-06

  

  According to the labeling of dabigatran in Japan, patients to be considered for the prescription of the lower dose of 220mg/day are as follows: (1) aged ≥70 years, (2) with moderate renal impairment (ClCr 30–50mL/min), (3) concomitant use of a p-glycoprotein inhibitor, and (4) history of hemorrhage

• Pregnancies in adolescents year olds and

  2019-05-06

  

  Pregnancies in adolescents (10–19-year-olds) and in older women (≥35 years) are hazardous for the mother and the child. Despite an almost universal decline in the adolescent alkylation of dna since 1990, adolescent fertility still accounts for 11% of all births worldwide, with 95% of these births o

• Lastly it is equally important

  2019-05-05

  

  Lastly, it is equally important to mention that the microenvironment and genetic background of the host with a previous history of two independent malignancies may have further facilitated the selective proliferation of a clone with trisomy 11 [9,10], while normal progesterone receptor suffered prol

• Idelalisib demonstrates a dual mechanism of

  2019-05-05

  

  Idelalisib demonstrates a dual mechanism of action by inhibiting pro-survival signalling pathways [6], and, like other kinase inhibitors, leads to re-localisation of tumour AL 8697 by blocking ingress into and promoting egress out of the lymph node into the blood. Release from the protective lymph

• Second political regime does very little to explain

  2019-05-05

  

  Second, political regime does very little to explain differences between countries. Rwanda, Congo (Brazzaville), and Tanzania have very similar child mortality rates (between 40 and 60 deaths per 1000 livebirths in 2014) to South Africa, Botswana, and Namibia despite the former countries being consi

• After overdrive pacing excitation that is one lap behind

  2019-05-05

  

  After overdrive pacing, excitation that is one lap behind (the second beat after the stimulus) is caused by several mechanisms. One is the prolonged conduction time that is longer than the TCL due to a long conduction pathway and/or slow conduction. The other is the dual-loop reentry [12]. The excit

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