• br Hybrid approach It is still

  2019-05-07

  

  Hybrid approach It is still not certain whether a single or a staged approach is safer and more effective. Natale et al. [31] performed a combined closed-chest epicardial monopolar radiofrequency ablation through a transabdominal transdiaphragmatic single port and catheter-based transseptal endoc

• br Conflict of interest br Introduction Osteosarcoma is one

  2019-05-07

  

  Conflict of interest Introduction Osteosarcoma is one of the most common primary bone tumor and occurs predominantly in children and young adults [1]. With the development of multiple therapeutic strategies including wide tumor excision, neoadjuvant or adjuvant chemotherapy, and radiotherapy,

• This study addresses an important question about whether rou

  2019-05-07

  

  This study addresses an important question about whether routine clinic follow-up after medical abortion can be responsively eliminated from service delivery protocols, thus reducing a key barrier to accessing medical abortion. Such a service change could be especially beneficial for women in rural,

• The Sustainable Development Goals can be

  2019-05-07

  

  The Sustainable Development Goals can be achieved through environmental prevention of diseases without an additional burden on resources. The WHO avoidable early environmental exposures initiative emphasises that the unrecognised health risks are most damaging to the human population. An absence of

• In terms of outcome based assessments we analyzed the

  2019-05-07

  

  In terms of outcome-based assessments, we analyzed the primary outcomes in both the 7-day and in-hospital mortality, to evaluate further whether the cause of death would be related to acute illness or chronic comorbidities, and furthermore to ensure care quality in both units. Illness severity and t

• XMD8-92 Roux en Y gastric bypass surgery

  2019-05-07

  

  Roux-en-Y gastric bypass surgery is a common cause of malabsorption associated with hyperoxaluria in obese patients and those with malignancies. Postoperatively, patients may have steatorrhea, weight loss, and diarrhea, resulting in malabsorption syndrome, which would increase excessive intraluminal

• HCV does not kill the cells it infects

  2019-05-06

  

  HCV does not kill the more helpful hints it infects, but triggers an immune-mediated inflammatory response (hepatitis) that either rapidly clears the infection or slowly destroys the liver, causing the development of HCC and cirrhosis. The outcome is largely determined by the efficiency of the antiv

• mtor pathway Performing an ajmaline test in children is prob

  2019-05-06

  

  Performing an ajmaline test in children is problematic for 2 reasons. First, the test is apparently less sensitive in children than in adults. In fact, in 1 study, a repeat ajmaline challenge performed after puberty unmasked BrS in 23% of relatives with a previously negative drug test performed duri

• Contributors Conflicts of interest br Acknowledgments This r

  2019-05-06

  

  Contributors Conflicts of interest Acknowledgments This research was funded by the Bill & Melinda Gates Foundation. The views expressed herein are those GSK2126458 of the authors and do not necessarily represent the official policy or position of the Bill & Melinda Gates Foundation, Imperial Co

• Interim measures however are not nearly enough A massive

  2019-05-06

  

  Interim measures, however, are not nearly enough. A massive expansion of the blood donor pool is needed, but scaling up blood donation in the low-resource world is no easy task. WHO has long advocated a set of interventions to fortify a nation\'s blood supply, but countries will have difficulty solv

• br Genetic basis Similar to other

  2019-05-06

  

  Genetic basis Similar to other arrhythmia syndromes, Brugada and early repolarization syndromes are inherited diseases that are usually transmitted in an autosomal-dominant manner [26]. To date, 13 genes have been associated with Brugada syndrome. Loss-of-function mutations in SCN5A, encoding the

• br Conflict of interest br Introduction A large

  2019-05-06

  

  Conflict of interest Introduction A large number of recent reports suggest that early repolarization (ER) and J waves are associated with the occurrence of ventricular fibrillation (VF) [1–4]. In particular, the presence of J waves in global leads, including the inferolateral leads, is thought

• br Discussion Clinically HES may

  2019-05-06

  

  Discussion Clinically, HES may be separated into two subgroups: HES with, and HES without gene abnormality such as PDGFRA, PDGFRB, or FGFR1. The standard therapy of HES without gene abnormality is steroid; by contrast, the first-line therapy of HES with gene abnormality is imatinib. Although in-

• Surgery especially modified radical mastectomy is the gold

  2019-05-06

  

  Surgery, especially modified radical mastectomy, is the “gold standard” for the treatment of male breast cancer. Postoperative adjuvant radiotherapy is recommended for male patients with large breast cancer and axillary lymph node and chest muscle involvement; it can reduce the risk of local cancer

• According to the labeling of dabigatran in Japan patients to

  2019-05-06

  

  According to the labeling of dabigatran in Japan, patients to be considered for the prescription of the lower dose of 220mg/day are as follows: (1) aged ≥70 years, (2) with moderate renal impairment (ClCr 30–50mL/min), (3) concomitant use of a p-glycoprotein inhibitor, and (4) history of hemorrhage

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