• gsk3 Free fatty acids FFAs which are obtained from dietary f

  2022-03-23

  

  Free fatty acids (FFAs), which are obtained from dietary fat or endogenous synthesis, function as nutrients and signaling molecules. Studies have shown that free fatty gsk3 receptors 1–4 which are G-protein coupled receptors, bind free fatty acids and serve as receptors for these FFAs. Short chain F

• Nicotine Many extracellular matrix ECM proteins are ligands

  2022-03-23

  

  Many extracellular matrix (ECM) proteins are ligands and regulators of integrin/FAK signaling and are involved in various aspects of cancer progression, including growth, survival, invasion, and metastasis (Lu et al., 2012). Tubulointerstitial nephritis antigen-like 1 (Tinagl1), a secreted extracell

• The synthesis of substituted pyrimidinone carboxamides

  2022-03-23

  

  The synthesis of 2-substituted pyrimidinone carboxamides – is outlined in , . Treatment of readily accessible nitriles with N-methylhydroxylamine hydrochloride in the presence of BAY 61-3606 dihydrochloride provided the adducts , which were subsequently reacted with diethyl acetylenedicarboxylate

• br Materials and methods br Results br Discussion Type

  2022-03-23

  

  Materials and methods Results Discussion Type I ECa is associated with estrogen excess, obesity and hormone-receptor positivity. However, the function of ERα on ECa is considered complicated. The expression of ERα is reduced in grade III ECa clinical samples [13]. The high ERα expression is

• Introduction As a compound class

  2022-03-23

  

  Introduction As a compound class, histone deacetylase inhibitors (HDIs) have been remarkably successful in the treatment of T-cell lymphoma [1]. Vorinostat (suberanilohydroxamic agomelatine or SAHA) was approved by the FDA in 2006 for the treatment of cutaneous T-cell lymphoma [2], [3]; romidepsin

• The neotropical fish Prochilodus lineatus has been widely

  2022-03-23

  

  The neotropical fish Prochilodus lineatus has been widely used in experimental designs for being sensitive to variations in water quality and tolerant to laboratory conditions (Camargo and Martinez, 2006, Cazenave et al., 2014, da Silva and Martinez, 2014, Vieira et al., 2016). Concern and reports a

• Human GPR hGPR was originally

  2022-03-22

  

  Human GPR55 (hGPR55) was originally isolated in 1999 as an orphan GPCR with high levels of expression in human striatum (Sawzdargo et al., 1999) (Genbank accession # NM_005683.3). hGPR55 was mapped to human chromosome 2q37, and in the human CNS it is predominantly localized to the caudate, putamen,

• Nicotine Recognition and Repair of DNA Damage DNA is a

  2022-03-22

  

  Recognition and Repair of DNA Damage DNA is a reactive molecule that is continually challenged by both endogenous and exogenous insults 1., 2.. Cellular metabolites and their byproducts, environmental toxins, and radiation alter the chemical structure of DNA, producing a wide spectrum of DNA damage

• br Discussion br Concluding remarks There are potentially hu

  2022-03-22

  

  Discussion Concluding remarks There are potentially hundreds or thousands of G-quadruplexes which form within promoters, telomeres, RNA transcripts, and even LINEs and SINES [9,11,121,122]. As articulated previously [27], G-quadruplexes are easily targetable with heterocyclic aromatic compound

• br FXR FGF in the control of BAs synthesis

  2022-03-22

  

  FXR–FGF15/19 in the control of BAs synthesis The nuclear receptor FXR is the master regulator of BAs homeostasis, modulating their synthesis, Arylquin 1 receptor and uptake [15]. FXR decreases BA de novo hepatic biosynthesis by reducing the expression of CYP7A1. At the canalicular membrane, newl

• Introduction Risk factors for colorectal cancer

  2022-03-22

  

  Introduction Risk factors for colorectal cancer (CRC) include high-fat diets, sedentary lifestyles, obesity, diabetes, and elevated serum levels of toxic bile acids (BAs) (de Aguiar Vallim et al., 2013, Degirolamo et al., 2011, Downes and Liddle, 2008, Font-Burgada et al., 2016, Kuipers et al., 201

• Remarkably most of these molecules are also quite effective

  2022-03-22

  

  Remarkably, most of these molecules are also quite effective in interfering with the proliferation of the drug-resistant cancer cell lines, with IC50 values ranging from 0.59 to 2.93 μM against MCF-7/ADR cells, and from 0.160 to 1.17 μM against NSCLC-resistant H1975 cells. Among these molecules, com

• br Acknowledgments I thank Takeshi Sakaba for critical readi

  2022-03-22

  

  Acknowledgments I thank Takeshi Sakaba for critical reading of the manuscript and helpful comments. This work was supported by JSPS/MEXT KAKENHI Grant Numbers 17K19466, 17H03548. Introduction The oral route of drug application is the main route in pharmacology since it is easy to handle and o

• One limitation of our study was

  2022-03-22

  

  One limitation of our study was that all control dogs had histologic evidence of mild GI inflammation according to established WSAVA guidelines (Washabau et al., 2010), despite being apparently healthy purpose-bred research dogs housed in a controlled environment with no history of vomiting, diarrhe

• We are pursuing a hit to lead medicinal

  2022-03-21

  

  We are pursuing a hit-to-lead medicinal chemistry campaign to optimize inhibitors of the HBV RNaseH. Here, we report the activity of seven new HIDs and nine new HPDs, with significant improvements in in vitro potency and cytotoxicity profiles for the HPD compounds. Materials and methods Result

16129 records 497/1076 page Previous Next First page 上5页 496497498499500 下5页 Last page