• Tyr phosphorylation of AnxA was

  2021-11-15

  

  Tyr23 phosphorylation of AnxA2 was first reported to be involved in endocytosis, particularly in the internalisation of the insulin receptor [20]. Phosphorylated Tyr23 seems to be necessary for the stable association of AnxA2 with endosomes, and for their early-stage transport [14]. The role of AnxA

• The biochemical cell culture activities and properties

  2021-11-15

  

  The biochemical, cell culture activities and properties of bicyclic carboxamides are compiled in , with the prototype of the series, 4-fluorobenzyl carboxamide , displaying an antiviral profile comparable to the spirocyclic carboxamide . The introduction of a small hydrophobic methyl () and chloride

• The H R antagonist cimetidine Tagamet became the first billi

  2021-11-15

  

  The H2R antagonist cimetidine (Tagamet™) became the first billion-dollar drug in the 1980s for the treatment of peptic ulcer disease. Other H2R antagonists include ranitidine, famotidine, nizatidine, and zolantidine, the latter showing good BBB penetration with a steady-state brain/blood ratio of 1.

• Compared to the other histamine

  2021-11-15

  

  Compared to the other g-quadruplex receptor subtypes, the H3 receptor exhibits rather complex pharmacology, being subject to extensive splicing, leading to two major (H3-445 and H3-365) and possibly more functional human receptor isoforms; for a comprehensive review please see Leurs et al. (2005) a

• SB-334867 hydrochloride A few research articles described th

  2021-11-12

  

  A few research articles described that PLGA could alone improve physiological activities in certain illnesses by exerting therapeutic effects. These reported therapeutic activities of PLGA can be appended to the hydrolysis products of PLGA lactate, glycolate, and H+. We will recapitulate their respe

• br Endogenous lipids as SLC transporter modulators Lipids

  2021-11-12

  

  Endogenous lipids as SLC6 transporter modulators Lipids constitute part of the environment in which membrane-embedded transporters operate [62]. Endogenous lipids can act as inhibitory ligands [63] or functionally important components of the membrane that impart changes in transporter structure [

• br Regulation of the GLI code

  2021-11-12

  

  Regulation of the GLI code by non-HH signals and by the oncogenic load The GLI code may be seen as the essential parameter to regulate canonical HH output. Its regulation first appeared to be strictly dependent on the presence of specific levels of HH ligands. Indeed, GLI1 transcription is so far

• Thieno-GTP synthesis Gastric inhibitory polypeptide a hormon

  2021-11-12

  

  Gastric inhibitory polypeptide, a hormone belonging to the glucagon-secretin family of peptides, exhibits protection against the neurodegeneration and also stimulates neurogenesis in adult rats in a paracrine manner (Gault and Holscher, 2008, Nyberg et al., 2005, Usdin et al., 1993). The expression

• Furthermore our results are the first

  2021-11-12

  

  Furthermore, our results are the first to demonstrate that the stimulating effect of GALP on AVP release in rats is independent of galanin receptors. The same stimulatory GALP influence on AVP secretion has been also observed in the presence of galantide, an antagonist of Gal receptors in the incuba

• We show here that FXR

  2021-11-12

  

  We show here that FXR is a point of convergence of heredity (H) and environmental (E) risk factors for CRC (re the Tomasetti and Vogelstein model). Our studies demonstrate that the APC mutation and high-fat diet independently and cooperatively increase the BA pool that results in the repression of F

• To examine the biochemical characteristics of FPPS in Drosop

  2021-11-12

  

  To examine the biochemical characteristics of FPPS in Drosophila, DmFPPS has been functionally expressed in E. coli. The protein displays properties similar to mammalian FPPS, with some notable differences, including the ability to efficiently couple the homologous substrate, homodimethylallyl dipho

• br Nanoscale Cortical Actin Remodeling in Regulated Exocytos

  2021-11-12

  

  Nanoscale Cortical Actin Remodeling in Regulated Exocytosis The network of cortical Pertussis Toxin synthesis is formed by numerous fine actin filaments, which are only about 10nm in diameter [52]. Although the microscale role of the cortical actin network in vesicle exocytosis is well establish

• The above mentioned studies are especially important since

  2021-11-12

  

  The above-mentioned studies are especially important since the structural alterations of the peritoneum during peritoneal dialysis are very similar to vascular and tissue alteration seen in diabetes. The tissue alterations during long-term peritoneal dialysis include a thickening and replication of

• br Memories can last a lifetime

  2021-11-12

  

  Memories can last a lifetime, long after the transient events have passed. The fact that information stored in the alpha amanitin can outlast the environmental trigger implies that enduring cellular changes in the central nervous system underlie memory. Epigenetic modifications of DNA and chromati

• Recent studies in our laboratory demonstrated that several h

  2021-11-12

  

  Recent studies in our laboratory demonstrated that several histamine H1 receptor antagonists induce apo A-I gene expression while histamine itself represses it [20]. In humans, there are three histamine receptor genes (H1, H2, and H3) that code for G-protein-coupled receptors (GPCR's) which bind his

15790 records 549/1053 page Previous Next First page 上5页 546547548549550 下5页 Last page