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br Conflict of interest br Acknowledgments
2021-07-12
Conflict of interest Acknowledgments Part of this work was supported by Institut Francais en Egypte, and the Academy of Scientific Research and Technology in Egypt under the frame of “Imhotep Project N°: 31681XL” and “STDF/IFE project N° 30630″ Introduction NSAIDs play an important role in
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The Fontan circulation When first described in the
2021-07-12
The Fontan circulation When first described in 1971, the Fontan operation ushered in a new paradigm in the care of children born with the varied forms of complex congenital Gardiquimod disease (CHD) characterized by a single effective pumping chamber.1., 2. This procedure, which creates a total ca
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br Discussion We are reporting a cryptic
2021-07-12
Discussion We are reporting a cryptic insertion of chromosome 22 material (EWS) to the long arm of chromosome 11 (11q24, FLI-1) recognizable by FISH in Annexin V-Cy3 Apoptosis Kit Plus receptor exhibiting trisomy 8 as the sole cytogenetic anomaly. In ES and PNET tumors, trisomy 8 is the most comm
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br Transparency document br Introduction The cyclic nucleoti
2021-07-12
Transparency document Introduction The cyclic nucleotide adenosine 3′,5′-cyclic monophosphate (cAMP) exerts both an endothelium-dependent and an endothelium independent vasorelaxant action in rat Epigenetics Compound Library receptor [1]. cAMP direct, endothelium-independent vasorelaxant effe
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PI K is a lipid kinase and generates
2021-07-12
PI3K is a lipid kinase and generates phosphatidylinositol-(3,4,5)-trisphosphate, which is a second messenger critical for the translocation of Akt to the cytoplasmic membrane. The phosphorylation of Ser473 Akt is important in the cell survival by regulating the eNOS among other targets (Dimmeler et
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In a larger study of patients with nondiabetic proteinuric c
2021-07-12
In a larger study of 22 patients with nondiabetic proteinuric chronic kidney disease, BQ-123 produced significant natriuresis, resulting from increased renal blood flow. In addition, ETA antagonism reduced blood pressure and proteinuria, and, a new finding, decreased arterial stiffness. However, in
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br Discussion Although DNA has a limited chemical
2021-07-09
Discussion Although DNA has a limited chemical stability it has long been known that DNA in blood stains may remain relative stable for weeks, months, or even years at ambient temperature,1, 2, 3, 4, 5, 6 and samples (e.g., reference samples) that have been transferred to a matrix, e.g., FTA® pap
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br Conclusion br Conflict of interest br Introduction The
2021-07-09
Conclusion Conflict of interest Introduction The sexual exploitation and internal trafficking of British children within the UK has received growing public and policy attention in recent years. This has largely been in response to a number of high profile police investigations into cases in
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DPQ To understand more clearly how these activities are
2021-07-09
To understand more clearly how these activities are combined in the heterotrimeric enzyme and to understand more clearly how DNA alkylation might effect DNA helicase activity, we summarize the relevant features of the structure of RecBCD determined in the presence of DNA. The RecB and RecC subunits
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br Conclusion br Competing interests br
2021-07-09
Conclusion Competing interests Authors' contributions Acknowledgements The work was supported by Aurigene Discovery Technologies (M) Sdn. Bhd., Industrial Doctoral Program sponsorship by Ministry of Higher Education, Malaysia and research grants by the University of Malaya, grant number
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Introduction The term myeloproliferative disorders was
2021-07-09
Introduction The term “myeloproliferative disorders” was first proposed by William Dameshek in 1951. With the discovery of the Philadelphia chromosome, myeloproliferative disorders were classified into two groups: BCR-ABL positive chronic myeloid leukemia (CML) and BCR-ABL negative chronic myelopro
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br Conclusion In vivo pharmacokinetic studies
2021-07-09
Conclusion In vivo pharmacokinetic studies showed that dasatinib monohydrate pretreatment significantly decreased the blood level of CsA in rats, which was most probably due to the induction of CYP3A2 isoenzymes. The nilotinib pre-treatment had no significant effects on cyclosporine pharmacokinet
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In this study we further investigated the involvement of
2021-07-09
In this study, we further investigated the involvement of CRF1 and CRF2 receptors of the dPAG in the regulation of panic-related responses. For this, we used two animal models that associate escape behavior with panic attacks: the elevated T maze and the electrical stimulation of the dPAG (for a ful
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Completion of h of education
2021-07-09
Completion of 150 h of education was significant in virtually all prior studies of the 150-h requirement (Allen and Woodland, 2006, Boone et al., 2006 and others). While the 150-h requirement applies to licensure, students are often permitted (as in California) to sit for the CPA exam with fewer tot
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br Materials and methods br Results br Discussion
2021-07-09
Materials and methods Results Discussion The main finding of the present study is that selective ETA and dual ETA/ETB receptor blockade markedly improve endothelium-dependent vasodilatation in patients with type 2 diabetes and vascular complications. The magnitude of improvement did not dif
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