• Ultimately we decided to investigate the role of Cyp a

  2020-08-10

  

  Ultimately, we decided to investigate the role of Cyp3a in obesity because Hepatic P450 Reductase-null (HRN) mice with no P450 activity show hepatic steatosis with increased Cyp2b10 and Cyp3a11 expression, perturbations in liver size, lipid homeostasis, and increased liver polyunsaturated fatty acid

• Autophagy is a dynamic process that primarily involves autop

  2020-08-10

  

  Autophagy is a dynamic process that primarily involves autophagosome formatting and lysosomal degradation, and these processes are controlled by autophagy-related genes (Atg) (Klionsky et al., 2012). The related protein SQSTM1/p62 (sequestosome 1) importantly serves as a signalling director in sever

• SCH 58261 synthesis To respond to the need for QNAT commerci

  2020-08-10

  

  To respond to the need for QNAT, commercial assays have been developed on automated systems. The first reagents for CMV and EBV VLs in whole blood were Abbott RealTime kits on the m2000 SP/RT system (Abbott Molecular Inc, Des plaines, USA) (M2000) [4,5] and Artus QS-RGQ kits on the QIAsymphony RGQ s

• br Conclusion This patient was hypercoaguable as evidenced b

  2020-08-10

  

  Conclusion This patient was hypercoaguable as evidenced by a lower extremity DVT, pulmonary emboli, and a splenic infarct. Excluding acute CMV infectious mononucleosis, she had no disorders predisposing to splenic infarcts.4, 5 In this case, CMV infectious mononucleosis was accompanied by CMV lun

• We recently employed a functional drug screening approach

  2020-08-10

  

  We recently employed a functional drug screening approach to identify mithramycin as an inhibitor of EWS–FLI1. In our study, we employed a stepwise approach involving a luciferase primary screen and a novel multiplex PCR screen to evaluate over 50,000 compounds to identify mithramycin as an inhibito

• br Activatable optical imaging probes Optical

  2020-08-10

  

  Activatable optical imaging probes Optical fluorescence imaging, which directly detects photons emitted from fluorescent probes, has become as a powerful analytical method to study biological processes both in vitro and in vivo. It is characterized by high sensitivity, is free of radioactive irra

• Regarding eicosanoid production iPLA VIA appears

  2020-08-10

  

  Regarding eicosanoid production, iPLA2-VIA appears, in general terms, not to play a major role in mediating this response in innate immunity and inflammation, as evidenced by the large number of studies highlighting the lack of effect of selective inhibition of the enzyme in stimulus-induced AA rele

• br Introduction Abdominal aortic aneurysm AAA is a daily con

  2020-08-10

  

  Introduction Abdominal aortic aneurysm (AAA) is a daily concern in vascular surgery, as successful treatment is exclusively achieved by open or endovascular repair. Its prevalence is 2–11% among male smokers, and rupture the major complication, is associated with unacceptably high morbidity and m

• In contrast to inflammatory cytokines

  2020-08-10

  

  In contrast to inflammatory cytokines, TGF-β has immunosuppressive properties yet is also important for tissue imprinting immune cell function during development [23]. Salivary gland (SG) ILCs, in addition to liver and intestinal intraepithelial ILC1, express markers denoting tissue residency and TG

• The idea that ASB can drive compartment expansion in

  2020-08-10

  

  The idea that ASB11 can drive compartment expansion in the CNS is further supported by in vitro work in human neuronal precursors. Nerve growth factor (NGF)-induced differentiation of PC12 pheochromocytoma sr1 [11] and RA-induced human pluripotent teratocarcinoma carcinoma (NT2) cells [12] constitut

• If the factors needed for A NHEJ

  2020-08-08

  

  If the factors needed for A-NHEJ are not completely defined and the A-NHEJ reaction mechanism nebulous, it is also fair to say that the biological role(s) of A-NHEJ is even more poorly understood. Most of the current interest in A-NHEJ, however, stems from its implicated use in the chromosomal trans

• br Acknowledgments Denise Fernandes acknowledges a postdoc f

  2020-08-08

  

  Acknowledgments Denise Fernandes acknowledges a postdoc fellowship (SFRH/BPD/34289/2006) from the Portuguese Fundação para a Ciência e Tecnologia (FCT) of the Ministry of Science and Technology of Portugal. This work was supported by the Spanish National Plan for Research (Project Ref. CGL2011-24

• Terbinafine In summary the mechanism underlying the DBP indu

  2020-08-08

  

  In summary, the mechanism underlying the DBP-induced hippocampal neuron apoptosis in KM mice may be: Upstream molecular events: DBP can act on the hippocampus of the brain, resulting in ROS accumulation and excessive Ca2+ in the hippocampal neurons, thus activating the ERK 1/2 pathway; Midstream mol

• There are DUBs encoded in the human genome

  2020-08-06

  

  There are ∼100 DUBs encoded in the human PD123319 that can be classified into five different families: ubiquitin C-terminal hydrolase (UCH), ubiquitin-specific proteases (USPs), ovarian tumor (OTU), Josephins, and JAB1/MPDN+/MOV34 (JAMM). With the exception of JAMM family DUBs, which are metallo-pr

• br Experimental section br Biological activity protocol br

  2020-08-06

  

  Experimental section Biological activity protocol Molecular docking simulation Molecular docking experiments were performed using Glide software package [46] implemented in Schrodinger Suite (2017–2) (Schrödinger, Inc., USA) [47] running on Intel CORE i7 based hpZ230 workstation with the Mi

15714 records 803/1048 page Previous Next First page 上5页 801802803804805 下5页 Last page