• In this paper we focused on Ewing

  2020-10-09

  

  In this paper, we focused on Ewing sarcoma (ES), a rapidly growing, highly malignant bone tumor developing metastases in the vast majority of patients unless multiagent chemotherapy is applied [16]. ES is the second most frequent bone tumor in childhood and adolescence, and is characterized by the p

• In this study we also conducted an analysis comparing the

  2020-10-09

  

  In this study, we also conducted an analysis comparing the expression profiling of Hh genes among the sarcomas investigated. In these tumors, the IHH gene showed a higher expression level than PTCH1 gene in RMS and SS samples (p242 4 in human RMS cell lines as well as mouse NIH-3T3 fibroblasts. The

• Estrogen receptor related receptor ERR like other members of

  2020-10-09

  

  Estrogen receptor-related receptor γ (ERRγ), like other members of the ERR subfamily, is a constitutively active orphan nuclear receptor, though unlike ERRα and β, it is more selectively expressed in metabolically active and highly vascularized tissues such as heart, kidney, brain, and skeletal musc

• br Materials and methods br

  2020-10-09

  

  Materials and methods Results Discussion In particular, we showed that pancreatic neuroendocrine tumor muscarinic receptor antagonists recognize cAMP as a stimulatory signal for cell proliferation. Conversely, cAMP was found to have an inhibitory effect on cell proliferation in bronchial ca

• br Results br Discussion In this

  2020-10-09

  

  Results Discussion In this study, we investigated the role of EP4 on invasion and invadopodia in breast cancer cells. Our results demonstrate that EP4 activation promotes invadopodia-driven ECM degradation, in turn facilitating future intravasation and metastasis of breast cancer PJ34 (Gligori

• br Materials and methods br Results br Discussion Here

  2020-10-09

  

  Materials and methods Results Discussion Here we show expression of the EP1 receptor in the hippocampus of mice and the functional influence of the EP1 receptor on kainic cc-5013 induced seizures. Mice lacking a functional EP1 receptor gene displayed a lower tendency to enter status epilep

• Another enzyme class that has emerged as a potential

  2020-10-09

  

  Another enzyme class that has emerged as a potential alternative to P450s are the so-called ‘unspecific peroxygenases’ (UPOs). They also contain a heme but are extracellularly expressed fungal enzymes that are often more stable than P450 monooxygenases. Importantly, UPOs use H2O2 instead of O2 as th

• br Experimental Procedures br Acknowledgments br Introductio

  2020-10-09

  

  Experimental Procedures Acknowledgments Introduction The ability of the affiliative and nurture hormone oxytocin (OT) to attenuate stress has been observed across psychological, neurological, and physiological levels [1], [2]. We and others have demonstrated that, in the gut, OT can lessen

• br Conflicts of interest br Acknowledgements This work

  2020-10-09

  

  Conflicts of interest Acknowledgements This work was supported by the Swiss National Science Foundation No 31003A-179400 to AO. We thank Dr. Thierry Langer, University of Vienna and Inte:Ligand GmbH, for providing the LigandScout Software, and Dr. Daniela Schuster, Paracelsus Medical Universit

• br Materials and methods br

  2020-10-09

  

  Materials and methods Results Discussion The incretin hormones potently stimulate insulin secretion, and it is generally assumed that this is mediated by an endocrine mechanism such that GIP and GLP-1 through the circulation reach the islet beta SH-4-54 australia to stimulate their secreti

• br Materials and methods br Results

  2020-10-09

  

  Materials and methods Results Discussion Drug of abuse induces widespread MnTBAP Chloride australia changes in the molecular and cellular functions in circuits between VTA and its neighbored regions such as NAC, and amygdala. It is belived that these changes result behavioral phenotype tha

• DGK type I http www

  2020-10-08

  

  DGKη1 (type II DGK) has a separated catalytic domain [10], [13], whereas the domains of DGKα, ε and ζ are not split [1], [2], [3], [4], [5]. Therefore, the structural difference may cause the distinct affinity for DG among these isozymes. Because other type II DGKs (η2, δ1, δ2 and κ) also have the s

• As a functional ETC is required

  2020-10-08

  

  As a functional ETC is required for DHODH catalysis (Loffler, Jockel, Schuster, & Becker, 1997; Rawls, Knecht, Diekert, Lill, & Loffler, 2000; Zameitat, Freymark, Dietz, Loffler, & Bolker, 2007), DHODH depends on the mitochondrial ETC to generate adequate concentrations of ubiquinone (Fig. 2). Cells

• br Results br Discussion The most relevant

  2020-10-08

  

  Results Discussion The most relevant overall finding was that DDR1 is present in myelin and is probably synthesized by oligodendrocytes. This result was supported by three different approaches. First, we detected presence of DDR1 mRNA in myelin by ISH. Second, the pattern of DDR1 immunostainin

• In order to assess quantitatively the contribution

  2020-10-08

  

  In order to assess quantitatively the contribution of the ung, dug and dut hsp90 inhibitors to uracil-DNA accumulation in E. coli, we have developed a novel method for measuring uracil residues in DNA that is based on the approach of Kow and co-workers [33] for measuring AP-sites in DNA. The method,

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