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br Conclusion br Introduction Biological wastewater treatmen
2020-07-16
Conclusion Introduction Biological wastewater treatment is targeted towards the removal of phosphorous, nitrogen and organic substances by the metabolic activity of a diverse activated sludge microbial community. More precisely, it is based on the versatile catalytic activity of the microbial
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Models and theories The CPA equation of state
2020-07-15
Models and theories The CPA equation of state is composed predominantly of two parts: physical item and the association item based on the thermodynamic perturbation theory [21], [22], [26], [27]. The physical item is used to represent intermolecular physical interaction, usually representing the SR
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These data indicate that in the context of
2020-07-15
These data indicate that, in the context of the N-terminal 42 amino acids of p53, threonine 18 is a substrate for phosphorylation by CK1 as mediated by prior phosphorylation of serine 15. To determine whether this is a property of full length p53, GST-p53 fusion proteins comprising the full length p
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pentylenetetrazol mg Therefore the SPH algorithm in AUTODYN
2020-07-15
Therefore, the SPH algorithm in AUTODYN-3D™ was used to simulate the experiment in Ref. [5] to verify the credibility of the numerical simulation method by results that could be measured accurately. Then the verified numerical simulation method was used to simulate BAD generated by RHA subjected to
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Importantly we observed significantly the reduced myocardial
2020-07-15
Importantly, we observed significantly the reduced myocardial infarct size, the improved left ventricular function and the inhibited fibrosis after I/R with oral GA-BH4 supplementation before ischemia (Fig. 1, Fig. 2, Fig. 3). Usually, there is a view that the antioxidation induced by reducing agent
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Epothilone D Accordingly we prepared three compounds
2020-07-15
Accordingly, we prepared three compounds (, , and ) as shown in . Condensation of commercially available Epothilone D with glycine methyl ester gave amide . A Friedel–Crafts reaction between compound and 4-methyl valeryl chloride in the presence of aluminum chloride mainly produced undesired com
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br Materials and methods br Results In
2020-07-15
Materials and methods Results In the leaves of the studied varieties, one to three nucleoli per nucleus were observed (Fig. 1a), except for the variety Bastardo were a maximum of two nucleoli per nucleus were detected. In the root-tip cells, most of the varieties presented one to three nucleo
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During the past three decades platinum based DNA alkylating
2020-07-15
During the past three decades, platinum-based DNA-alkylating agents have been employed in the treatment of various cancers [14]. Oxaliplatin is currently used as a first-line treatment for colorectal cancer (CRC) [15]. Unfortunately, a large portion of CRC patients receiving oxaliplatin-based chemot
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Previous synthetic lethal screening efforts Cox
2020-07-15
Previous synthetic lethal screening efforts (Cox et al., 2014) have mainly used RNAi as a means of identifying potential targets (Barbie et al., 2009, Kim et al., 2016, Luo et al., 2009, Scholl et al., 2009), although a few screens (Shaw et al., 2011, Steckel et al., 2012) have been performed with s
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fty720 Investigations of mice lacking up to three CDKs ident
2020-07-15
Investigations of mice lacking up to three CDKs identified the mitosis-regulating kinase CDK1 as the main essential component for the cell cycle, whereas ablation of other fty720 regulators such as CDK2, CDK4, or CDK6 did not result in defective proliferation 12, 13. Mouse models and specific CDK i
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The significant CRF increase in the DS and the
2020-07-15
The significant CRF increase in the DS and the overall changes in the CRF system observed in the VM and DS during the development of sensitization suggest that this neuropeptide (and possibly urocortin) contributes to the specific molecular alterations occurring in the mesolimbic pathway that suppor
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Overall the evidence and the results from
2020-07-14
Overall, the evidence and the results from in vivo studies clearly indicate that cyclosporine biotransformation can be induced by dasatinib co-administration through induction of CYP3A expression. However, further studies are needed to explore the role of P-gp modulation in DDIs. Conclusion In v
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PTEN is an evolutionarily conserved protein and has
2020-07-14
PTEN is an evolutionarily conserved protein and has been considered to be genetically unique without other isoforms. In this study, we identified an alternate translation initiation at a CUG site in the 5′ untranslated region (5′ UTR) of PTEN mRNA. This CUG start A 61603 hydrobromide generates a la
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It is of interest to
2020-07-14
It is of interest to consider an explanation for the apparent phosphorylation of hSSB1 in undamaged cells. One such may be that in order to execute a rapid response to replication inhibition, basal S134 phosphorylation could function to keep hSSB1 in a ‘primed’ state prior to stress. Such an arrange
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Importantly piPolB holds a great promise for developing nove
2020-07-14
Importantly, piPolB holds a great promise for developing novel biotechnological applications. For instance, in vitro activities of piPolB, namely, strand displacement and faithful, processive DNA polymerization, can be harnessed for efficient primer-independent whole-genome amplification, whereas th
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