• br EBI structure and expression The gene encoding

  2020-01-17

  

  EBI2 structure and expression The gene encoding EBI2 was originally identified together with EBI1 (CCR7) as the most highly upregulated gene in Epstein–Barr virus-infected Burkitt\'s lymphoma cells [18]. EBI2 belongs to the rhodopsin-like subfamily of seven transmembrane GPCRs [19]. Although it i

• Given the link between E s autoimmunity and antitumor immuni

  2020-01-17

  

  Given the link between E3s, autoimmunity, and antitumor immunity, it bioactive is reasonable to assume that, similar to other ICBs, IRAEs may limit the clinical use of E3-targeting therapies – further stressing the need to better understand the underlying mechanisms of these unwanted effects. Despi

• br Author Contributions br Acknowledgments br Introduction

  2020-01-17

  

  Author Contributions Acknowledgments Introduction Osteoporosis is a common bone disease that frequently leads to disruption of the alveolar and systemic bones with age. Novel osteoanabolic strategies to treat osteoporotic bone loss or augment fracture repair efficiently are desired. Since b

• CFSs are recognized as a driver

  2020-01-17

  

  CFSs are recognized as a driver of genome instability in human cells and are hotspots for deletions or translocations in cancers (Richards, 2001). The generally accepted model for their expression is that the CFS locus shows a delay in chromatin condensation in early mitosis caused by the persistenc

• br Discussion EFTs are sarcomas with almost

  2020-01-16

  

  Discussion EFTs are sarcomas with almost undifferentiated histologic features, consequently their differentiation from other small, blue, round cell tumors may be difficult. Substantial intracellular mycophenolic acid on PAS stain is a useful diagnostic feature. The addition of CD99 and FLI1 imm

• br Materials and methods br

  2020-01-16

  

  Materials and methods Results and discussion Conclusion The glycyl endopeptidase from papaya latex was partitioned using aqueous two-phase (10%PEG 6000–10% (NH4)2SO4) in combination with ammonium sulphate precipitation (40–60% saturation). The partially purified glycyl endopeptidase showed

• br Methods br Discussion and conclusions There were no

  2020-01-16

  

  Methods Discussion and conclusions There were no statistically significant differences in pulmonary function outcomes (FEV1 and FVC) between the placebo and BAY 85-8501 treatment groups. The decline in mean FEV1 from baseline to EOT in the placebo group was attributed statistically to a few pa

• Our study found a significant association

  2020-01-16

  

  Our study found a significant association between the degree of primary tumor lobulation and EGFR mutations status (P EGFR Ciclopirox receptor status. However, only a small portion of these previous studies included the evaluation of lobulation, and almost all of them reported no association betwee

• CCR is another chemokine receptor that

  2020-01-16

  

  CCR7 is another chemokine receptor that is upregulated in CLL [3], [61], [71], [96] and is believed to play a role in enabling cell entry into lymph nodes [97]. Higher mRNA and protein expression of CCR7 has been observed in unmutated compared to mutated IGHV CLL [46] and increased expression has be

• DNA damage represents a persistent threat to genomic

  2020-01-16

  

  DNA damage represents a persistent threat to genomic stability. A critical link exists between DNA mutation, chromosomal rearrangement and cancer development. In myeloid malignancies, various chromosomal translocations and/or mutations increased cellular reactive oxygen species (ROS), followed by DS

• Compound was advanced to a chronic efficacy study in

  2020-01-16

  

  Compound 52 was advanced to a chronic efficacy study in db/db mice maintained on a high fat diet. Animals were dosed with 0.5% methylcellulose vehicle, Caspase-1, human recombinant proteinase 52 (1, 3 or 15mg/kg, po, Q.D.) or 1 (0.3mg/kg) for 14days. Over the course of the study body weight and foo

• Two major mechanisms including apoptosis and oxidative stres

  2020-01-16

  

  Two major mechanisms including apoptosis and oxidative stress have been suggested for MTX-induced cytotoxicity (Hafez et al., 2015; Neuman et al., 1999; El-Sheikh et al., 2015). It has been reported that MTX promotes cell death via apoptosis in both cancerous and non-transformed cells (Mazur et al.,

• br Structure of USP Schematic representation of the

  2020-01-15

  

  Structure of USP7 Schematic representation of the USP7 domain architecture is shown in Fig. 3B. USP7 is a 135 kDa protein that consists of seven domains, including the N-terminal TRAF-like (Tumor necrosis factor Receptor–Associated Factor) domain, followed by the catalytic core domain and the fiv

• To function as Ub ligases E proteins must interact

  2020-01-15

  

  To function as Ub-ligases, E3 proteins must interact with E2s. As compared to the extensive studies on E3s, functional studies on E2s are relatively rudimentary in higher plants. We previously reported that there are 48 genes encoding Ub-conjugating (UBC) fold-containing putative E2 proteins in the

• br Discussion Several DPP inhibitors are currently available

  2020-01-15

  

  Discussion Several DPP-4 inhibitors are currently available for use in the treatment of type 2 diabetes mellitus. Due to the different chemical structures there are marked differences both in the binding kinetics on the target enzyme [10] and also different pathways of elimination [13] exist. In

15705 records 902/1047 page Previous Next First page 上5页 901902903904905 下5页 Last page