• br Conclusions br Acknowledgements br Introduction Liver can

  2019-10-09

  

  Conclusions Acknowledgements Introduction Liver cancer was the fifth most common cancer and the second leading cause of cancer-related death worldwide [1]. Most of primary liver cancers (70–90%) occurring worldwide are hepatocellular carcinoma (HCC) [2]. Persistent hepatitis B virus (HBV) i

• BMS-387032 br The modulation of ER from SERMs to TSECs Conti

  2019-10-08

  

  The modulation of ERα: from SERMs to TSECs Continued efforts to provide women with efficacious menopausal therapies have generated interest in the development of selective BMS-387032 receptor modulators (SERMs). Similar to estrogens, SERMs have been shown to bind to ERs with high affinity, despit

• Agarose GPG/LMP low melt and Methods br Results br Discussio

  2019-10-08

  

  Methods Results Discussion It is well established that CRSwNP is characterized by TH2 inflammation and eosinophilia.22, 27 Yet it is becoming increasingly apparent that B cells might play an important role in the inflammatory response within the sinus tissue of patients with CRSwNP.8, 9 The l

• Other GPCRs notable for changes

  2019-10-08

  

  Other GPCRs notable for changes in expression on CLL cells include upregulation of the thromboxane A2 receptor TBXA2R mRNA [61] and up and downregulation of mRNA and protein from the neurotensin receptors NTSR2 and NTSR1, respectively [62]. The Eμ-TCL1 mouse model of CLL has been used to study mult

• induced pluripotent stem cells ICT is a product of icariin v

  2019-10-08

  

  ICT is a product of icariin via the metabolism of intestinal bacteria with estrogen-like activities [33]. ICT as a bone-protecting agent can enhance osteoblast differentiation while suppressing osteoclastic differentiation in vitro [19], and stimulate osteogenic differentiation and inhibit adipogene

• In a study carried out by Aunis

  2019-10-08

  

  In a study carried out by Aunis et al. the properties of soluble DBH and membrane bound were examined [23]. The membrane bound enzyme was shown in ML-099 to the soluble form to have thermal denaturation at higher temperatures of 43.5–44°C. Similar discontinuities in the Arrhenius plots were obtaine

• In conclusion we developed a new CysLT and CysLT receptors

  2019-10-08

  

  In conclusion, we developed a new CysLT1 and CysLT2 receptors-mediated anaphylaxis guinea pig model that can be useful for screening both CysLT2 receptor and CysLT1/2 receptor antagonists. In addition, we have shown that the dual CysLT1/2 receptor antagonist ONO-6950 can exert protective effect agai

• br Results br Discussion SDF

  2019-10-08

  

  Results Discussion SDF-1 performs essential roles in cell migration and proliferation, acts as neuromodulator; and is also involved in many pathological processes including human immunodeficiency virus infection, metastatic malignancy, and chronic inflammatory disorders (Feng et al., 1996, Li

• CXC chemokines are primarily expressed in immune organs

  2019-10-08

  

  CXC chemokines are primarily expressed in immune organs and the central nervous system: the mouse thymus and spleen (Heesen et al., 1996), chicken bursa (Liang et al., 2001), primate (Macaca mulatta) AZD6738 clinical (Federsppiel et al., 1993) and cattle locus coeruleus, cerebellum and pons (Rimlan

• Arctigenin According to these results the power GaN seems

  2019-10-08

  

  According to these results, the power GaN seems more robust than existing technologies (VDMOS, Superjunction, IGBT,) [5,10] and [11]. Comparing with the SiC technology, the previous works show a low SEE tolerance [[12], [13], [14]] and [15]. The SOA of power GaN devices can be equivalent to the IGBT

• In cholesterol synthesis HMG CoA reductase

  2019-10-08

  

  In cholesterol synthesis, HMG-CoA reductase is the rate limiting step in cholesterol biosynthesis. Statins or HMG-CoA reductase inhibitors are commonly used for management of hypercholesterolemia. The presence of an HMG-like moiety on these drugs allows them to competitively bind to the catalytic do

• MOG (35-55) Phosphorylation of small GTPases has been also o

  2019-10-07

  

  Phosphorylation of small GTPases has been also observed to affect binding affinity for the GDP/GTP cycle regulators notably GDP dissociation inhibitor (GDI) [10]. Indeed the EGF or cAMP-dependent phosphorylation of Cdc42 is associated with enhanced Cdc42–GDI interaction [8], [11]. RhoA inhibition by

• br Introduction Breast cancer is

  2019-10-07

  

  Introduction Breast cancer is the most common cancer in women and one of the leading causes of death worldwide. Estrogen receptor alpha (ERα, “wild-type” estrogen receptor), encoded by the estrogen receptor1 (ESR1) gene, is expressed in approximately 70% of all breast cancers. Hormonal therapy ha

• br Enzyme activations Activated proteinases

  2019-10-07

  

  Enzyme activations Activated proteinases can unleash a deluge of tissue damage (Zucker et al., 2009). Once activated, the essential enzymes such as serine proteases and cysteine proteases cannot discriminate between self and non-self, burning away self-tissues (Chien et al., 2009, Laskar et al.,

• Terbinafine kinase br Conflict of interest br Acknowledgemen

  2019-10-07

  

  Conflict of interest Acknowledgements This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP: 2014/00926-3). Introduction The metacestodes of Taenia solium are the causative agent of cysticercosis, which mainly resides the skeletal muscles and the central n

15636 records 953/1043 page Previous Next First page 上5页 951952953954955 下5页 Last page